Neuroscience is growing scientific area comprising a variety of multidisciplinary investigations that seek to understand the relationship between the body and brain. The brain and its functions might be influenced by several factors such as physical exercise, aging, stress, environment, diet that called brain plasticity. Brain plasticity refers to the capacity of the nervous connection system to change its structural, functional and molecular levels. Brain plasticity include the ability for the brain to recover central nervous system (CNS) after disorders or injuries and to ameliorate the altered structures due to pathologies such as neurodegenerative disease, Alzheimer disease, Parkinson disease, mental illness etc. Especially, physical exercise plays a critical role on this brain plasticity. Exercise offers considerable health benefits to the physiological, psychological, social effects. How does brain plasticity change and what conditions of exercise are applied? This is a highly important issue for non-pharmacological therapeutic and genetic research. That offers the enormous answers, while yet others undergo no change at all or reverse the changing trend. The effects of physical exercise on the structures and functions of the CNS have received increasing attention from the neuroscience. These effects have been applied to studies of the health promotion, exercise science and sports performance. In this review, we provide the recent advances in the beneficial effects of exercise on brain function and highlight sports research.

It is well known that physical activity is effective for enhancing both aerobic capacity as well as brain function. A number of studies have shown that exercise-induced improvements in CNS such as synaptic plasticity, and hippocampal neurogenesis is thought to play a crucial role in enhancing cognitive functions, including learning and memory (van Praag et al., 1999; Yamada et al., 2018). A report on the processes of synaptic plasticity and neurogenesis have shown that the battery of clinical exercises for brain stimulation designed by brain fitness encourages creation of new synapses and neural circuits able to reorganize function of damaged area with compensatory transmission capabilities by physical exercise (Lourenco et al., 2019). Synaptic plasticity is perhaps the support on which the brain’s amazing malleability rests.

Whereas synaptic plasticity is achieved through enhancing communication at the synaptic site between existing neurons, neurogenesis refers to the birth and proliferation of new neurons in the brain throughout whole life (Altman and Das, 1965). When engaged in new experiences and learning, the brain establishes a series of neural pathways. These neural pathways, or circuits, are routes made of interconnecting neurons. Physical exercise enhances hippocampal neurogenesis and spatial memory related to brain-derived neurotrophic factor (BDNF) (Sun et al., 2017). These newly generated neurons in a neural pathway communicate with each other through synaptic connections. A better connection between the neurons means that the electric and chemical signals travel more efficiently when creating or using a new pathway. These results suggest that exercise enhances not only structural levels but also functional levels such as learning and memory in individuals.

The relationships between physical exercise and academic achievement in school-age children, demonstrated significant and positive correlations (Fedewa and Ahn, 2011). In particular, researchers show that brain plasticity is activated and strengthened by applying this clinical intervention exercise program (Gomes-Osman et al., 2017; Voss et al., 2013). An acute mild exercise improves the executive functions in young adults (Byun et al., 2014). Furthermore higher fitness group had better performance (Suwabe et al., 2017). Also, in the animal studies both wheel and treadmill exercise enhanced animal’s performances in Morris water maze (Lee et al., 2012), object recognitions (Robison et al., 2018), Y-maze (Van der Borght et al., 2007), and passive avoidance (Liu et al., 2008) that have been demonstrated on cognition improving in hippocampal associated learning and memory for rodents. Reconsidering the neural circuit and reestablishing neuronal transmission between the implicated neurons at each new attempt enhances the efficiency of synaptic transmission. Communication between the relevant neurons is facilitated, cognition made faster and faster. Functional level with behavioral development seems ideal for inducing brain plasticity. It provides the systematic practice necessary for establishing new neural circuits and for strengthening the synaptic connections among the neurons in the circuit.

The mechanisms underlying exercise-induced neuroplasticity involve molecular level with several neurotrophic and growth factors. Among them, BDNF is a well-characterized mediator of neuronal growth, plasticity, and survival (Hohn et al., 1990; Vaynman et al., 2003). Human and animal studies collectively suggest that exercise is an active strategy to up-regulate the expression of BDNF, which plays an essential role in exercise-induced neuroplasticity (Cotman and Berchtold, 2002; Neeper et al., 1995; Szuhany et al., 2015). Insulin-like growth factor (IGF)-1 is also a key modulator of neuronal functions in the CNS, including synaptic plasticity, synapse density, neurotransmission, neurogenesis and neuron differentiation (Aleman and Torres-Alemán, 2009). Chronic exercise-enhanced hippocampal neurogenesis, learning and memory performance have been attributed to IGF-1 signaling in the hippocampus (Cetinkaya et al., 2013). Voluntary exercise is known to increase the expressions of vascular endothelial growth factor (VEGF) and its receptors (Stevenson et al., 2018). VEGF, an angiogenic protein, is known to have neuroprotective and neurotrophic functions, it can be synthesized and released by peripheral vascular endothelial cells and brain cells, including astrocytes, ependymal cells, and neuronal stem cells (Nowacka and Obuchowicz, 2012).

Also, nerve growth factor (NGF) plays a role in promoting neuronal function, especially the survival of neural progenitors. The expressions of hippocampal NGF and one of its receptors, tropomyosin receptor kinase A (TrkA), are increased after 8 weeks of treadmill running in rodents. Similar to BDNF/tropomyosin receptor kinase B (TrkB) signaling, the binding of NGF to TrkA stimulates the downstream transcription factor, c-AMP response element binding protein, and induces various gene transcriptions related to cell survival and neuroplasticity (Frielingsdorf et al., 2007). Higher levels of BDNF and TrkB receptor in the hippocampus exhibit better performance in radial water mazes (Alomari et al., 2016) and passive avoidance tasks (Berchtold et al., 2010), blocking the TrkB receptor with antagonist inhibits the efficacy of exercise induced up-regulation of synaptic plasticity related proteins significantly, resulting in a disruption of benefits on cognitive function (Ko et al., 2018; Vaynman et al., 2003). All together, exercise seems to be capable of increasing the production of molecular levels in the brain of subjects and the translation of synaptic plasticity related proteins, which finally improves neuroplasticity.

Human and animal studies indicate that physical exercise has favorable effects on brain function. Various types of exercise set into motion an interactive cascade of growth factor signaling that has the net effect of stimulating structural changes, enhancing behavioral development and stimulating molecular levels. For example, it is ingenious to note that acute and chronic voluntary resistance wheel running with 30% of body weight led to greater enhancements, including adult hippocampal neurogenesis and cognitive functions, in conjunction with hippocampal BDNF signaling (Lee et al., 2012; Lee and Soya, 2017). There is no doubt that brain health could be improved through this physical exercise. Exercise benefits neuroplasticity in health and disease stages by targeting different aspects of brain function.

Although, it has been made dramatic accumulation of evidence of exercise neuroscience, there is a need for rigorous clinical intervention trials for further research. Physical, behavioral, and psychosocial barriers limit adequate uptake of exercise and engagement in physical activity. Accordingly, this inconsistency might due to different exercise conditions such as frequency, intensity, type, and time. It needs to identify and to target mechanisms by which exercise might act most synergistically with key treatments to improvements. Thus, it should be emphasized that exercise-induced changes in structural, functional and molecular levels may affect performance in both rodent and human (Fig. 1). Overall, studies of the exercise neuroscience aim to explore the effects of physiological and psychological on performance and mental health.