Effects of ninety minutes per week of continuous aerobic exercise on blood pressure in hypertensive obese humans

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J Exerc Rehabil Vol. 14, No. 1, 126-132, February, 2018

Publication date (electronic) : 2018 February 26

doi : https://doi.org/10.12965/jer.1835162.581

Felipe Lovaglio Belozo¹, Carlos K. Katashima², André V. Cordeiro¹, Luciene Lenhare^1,2, Jean F. Alves³, Vagner Ramon Rodrigues Silva^1,2,

¹Department of Sport Sciences, School of Applied Science, University of Campinas (UNICAMP), Limeira, Brazil

²Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil

³Department of Biochemistry, Faculty of Biology, University of Campinas (UNICAMP), Campinas, Brazil

^*Corresponding author: Vagner Ramon Rodrigues Silva, https://orcid.org/0000-0003-4793-1075, Department of Sport Sciences, School of Applied Science, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil, Tel & Fax: +55-19-3521-9038, E-mail: silvavagnerramon@gmail.com

Received 2017 November 17; Accepted 2018 January 17.

Abstract

INTRODUCTION

Systemic arterial hypertension (SAH) is a chronic disease that affects billions of people around the world. Hypertension causes millions deaths every year (Lim et al., 2012) and is a pivotal factor in the development of cardiovascular disease (CVD), which currently causes the largest number of mortalities per year (Lim et al., 2012). In SAH, the blood pressure (BP) is described as a systolic pressure of >139 mmHg over a diastolic pressure of >89 mmHg. This causes several pathologies, including coronary artery disease, loss of vision, acute myocardial infarction, stroke, heart failure, and renal failure (Moran et al., 2014). The complications associated with a high BP can stem from various factors, including environmental, nutritional and genetic factors and/or the interaction between these factors and a sedentary lifestyle (Appel, 2017). An elevated heart rate (HR) has been correlated with elevated BP, raising the risk of CVDs (Reule and Drawz, 2012).

A sedentary lifestyle has been described as a public health problem. Since 1995, in an attempt to improve interest in physical exercise, the World Health Organization has recommended a minimum of 150 min of physical exercise per week (Haskell et al., 2007). Conversely, regular exercise has been considered to act as a “medicine”; it plays a part in the prevention or treatment of several diseases (Stefani and Galanti, 2017) including SAH (Lim et al., 2016; Mancia et al., 2014). Furthermore, it reduces the risk of death from CVDs (Lear et al., 2017).

Out of several physical exercise protocols, aerobic exercise training (AET) is considered to be important for preventing or ameliorating elevated BP (Nascimento et al., 2017; Santos et al., 2016). Evidence suggests that different volumes, frequencies, and intensities of aerobic training can reverse several CVD pathologies (Brook et al., 2013; Mancia et al., 2014). In light of this, identifying new AET models with which to improve fitness in subjects with CVDs seems to be a good strategy. Thus, the main objective of this study was to investigate whether continuous aerobic training, performed 3 times per week on alternate days (a total of 90 min per week) at an intensity of 70%–80% of the maximal heart rate (MHR) could ameliorate the HR and BP in hypertensive obese humans.

MATERIALS AND METHODS

RESULTS

Table 1 shows all participants, grouping them by similarity in terms of age, sex and anthropometric profile considered obese according to the literature (Romero-Corral et al., 2008). Hypertensive obese humans trained for eight weeks (24 sessions), engaging in continuous treadmill aerobic exercise (90 min per week) and walking at an intensity of 70%–80% of the MHR (see MATERIALS AND METHODS section). Because an elevated HR is associated with elevated BP (Reule and Drawz, 2012), we checked whether the HR improved after the final session. Then we calculated the averages for the first session (1st) and last session (24th) session. No differences were detected between them (Fig. 1A).

Table 1

Descriptive characteristics

Fig. 1

Heart rate on the 1st and 24th session and correlation between heart rate and blood pressure (systolic/diastolic) of protocol exercise. Average heart rate (A), systolic (R=0.2867, P=0.1078) and diastolic pressure (R=0.4447, P=0.0509) correlated with heart rate up first session (B and D), systolic (R=0.5675, P=0.0253) and diastolic pressure (R=0.7083, P=0.0088) correlated with heart rate up last session (C and E). The analysis of heart rate was made between the 1st and 24th session of exercise. For Pearson correlation we used the 1st session of heart rate against the 1st session of systolic and diastolic pressure both after 15 min and 24th session of heart rate against the 24th session of systolic and diastolic pressure both after 15 min as well. *P<0.05.

Next, using Pearson correlation, we confirmed a positive correlation between HR and systolic pressure or diastolic pressure in the last session of exercise. We observed a significant improvement in systolic pressure (R=0.5675) and diastolic pressure (R=0.7083) values from the previous session (Fig. 1C, E). We did not observe significant differences in the first session (Fig. 1B, D). We examined the systolic (mmHg) and diastolic (mmHg) BP before and after 15 min of exercise in all 24 sessions. There was no statistically significant difference (Supplementary Fig. 1A, C). We also analysed the area under the curve for the systolic and diastolic BP before and after 15 min of exercise in all 24 sessions. We found no differences (P<0.2949 for systolic pressure) (P<0.2621 for diastolic pressure) (Supplementary Fig. 1B, D). We also evaluated the HR before, during and after each training session (Supplementary Fig. 2A–H).

Finally, to confirm the efficiency of our protocol exercise, we tested the ES according to the literature (Sullivan and Feinn, 2012). We found a large ES for systolic pressure (ES=0.85) and a small ES for diastolic pressure (ES=0.33).

DISCUSSION

CVD affect billions of people all over the world and are risk factors that have been directly correlated with comorbidity and mortality (Lim et al., 2012). Physical inactivity associated with hypertension cases is reported to accompany the risk for mortality (Bouchard et al., 2015). More than 5 million deaths are correlated with physical inactivity (Bouchard et al., 2015). On the other hand, regular exercise can be therapy for the whole body (Stefani and Galanti, 2017). In this context, AET is responsible for changes in cardiac events. The effects of AET are similar to pharmacological treatment and are considered to be responsible for ameliorating or attenuating high BP (Naci and Ioannidis, 2015). Different types of AET have been noted to prevent elevated BP (Cornelissen and Smart, 2013; Pescatello et al., 2004). However, aerobic training requires the control of variables such as the volume, frequency and intensity of training. Here, we use a continuous aerobic training strategy 3 times a week on alternate days to control BP in hypertensive obese humans.

Studies have suggested that short aerobic training may have positive effects on the BP when it is low in frequency, volume and intensity (Quinn, 2000; Wilmore et al., 2001). Moreover, research has shown that an intensity of up to 30 min of volume training more than 3 times a week may be helpful in addressing SAH (Brook et al., 2013; Mancia et al., 2014). In our study, we used continuous aerobic training three times a week on alternate days with a 30-min volume of training per session (90 min per week in total) and at an intensity of 70%–80% of the MHR as a strategy for improving the BP in hypertensive obese humans. Studies showed that aerobic exercise at an intensity of 50%–75% of the MHR was enough to ameliorate metabolic parameters such as BP in patients with T2DM (Santos et al., 2016; Zhang et al., 2017).

In our analysis, we did not observe significant differences between the HR and BP values before and after the training of hypertensive obese humans. However, when we analysed the correlation between BP and HR after the last (24th) session, we found it to be of strong statistical significance. Our results confirmed the findings in the literature that indicated that higher HR was associated with higher BP and could increase the risk of hypertension and CVD. In addition, it is important to highlight that the reduction of the HR, even to a small extent, is considered to be a therapeutic strategy and clinically important in hypertensive people (Reule and Drawz, 2012; Wilmore et al., 2001). Collectively, we established through the ES that our exercise protocol had a strong effect on the systolic pressure. According to the literature, the ES facilitates the understanding of the magnitude of the differences found (Sullivan and Feinn, 2012).

Although we instructed the individuals to continue pursuing their normal dietary habits, we did not control the food they consumed, nor did we measure the daily adverse events that may have occurred during the exercise intervention. Control of the diet is directly related to the maintenance of the BP and is defined as a major determinant of the development of hypertensiont (Appel, 2017; Lelong et al., 2017); this is especially the case for the consumption of sodium (O’Donnell et al., 2014). We were not able to guarantee that the patients would control their sodium consumption or diets as they were all obese. Lastly, we believe that the intensity and time of the pre- and postexercise evaluations facilitated the achievement of better BP results. Santos et al. (2016) found that exercising at a light intensity and at a moderate intensity (50% and 75% of the MHR, respectively) reduced the systolic pressure over 5 hr. Zhang et al. (2017) reported that engaging in aerobic exercise at an intensity of 70% of the maximal HR over a 12-week period was sufficient to reduce the markers of metabolic syndrome in T2DM patients. In our analysis, we evaluated the BP before exercise and 15-min postexercise. Perhaps that was why we did not observe a significant change in BP after the session. In light of this, more research is necessary to investigate the whole-body effects of the present protocol in depth, perhaps analysing the BP at different times after the exercise protocol as well as controlling food and sodium ingestion and the physical activity of individuals.

In line with these observations, we can conclude that our exercise protocol did not improve the BP and HR during and after the training of obese hypertensive humans over an 8-week period. However, we found a positively significant correlation between HR and BP through Pearson’s correlation analyses, an important parameter in the modulation of hypertension and a large ES in our protocol exercise. It is important to note that regular physical exercise can change several parameters which we did not analyse here and would probably would have significant effects on whole-body metabolism (Stefani and Galanti, 2017). Therefore, we suggest that the protocol involving aerobic physical training at a moderate-to-high intensity (70%–80% of the MHR) which the present study proposes may be an alternative strategy for encouraging more people with disorders and pathological conditions to exercise physically once the protocol is easy, fast and enjoyable to perform. In addition, our analyses demonstrate statistically significant correlation between the tendencies to improve the BP, HR, and other beneficial parameters in obese and hypertensive subjects. In this context, it is tempting to speculate that the present protocol, if performed for longer periods (e.g., inducing these individuals to follow a healthy lifestyle, engage in more than 8 weeks of intervention), would play a more statistically significant role in reducing BP in obese, hypertensive people. In addition, a recent study by Thum et al. (2017) demonstrated that physical exercise performed at higher intensities elicited higher enjoyment and adherence by subjects. This validated the protocol employed in the present study (augmenting the intensity and diminishing the volume of training). Our findings indicate that moderate CAE performed in thrice-weekly nonconsecutive sessions (90 min per week) by obese, hypertensive, diabetic and sedentary subjects showed positive correlations between a lower HR and lower BP. Moreover, we found that our protocol training had a large ES.

It’s important to highlight that this study has some limitations: first, we did not perform a metabolomics approach to investigating in depth the changes in the whole-body metabolism of the volunteers. In addition, the subjects were instructed to maintain their usual habits and not to improve their control of their food intake and physical activities. Last of all, the small sample size was a possible limitation. However, other studies showed that, where chronic physical exercise (e.g., training) was involved, a sample size of seven or more individuals was sufficient for the rigorous control of the statistical analysis (Damas et al., 2016). Similar studies involving humans used similar sample sizes to detect changes related to physical exercise (Combes et al., 2015; Parker et al., 2017). In general, though this study did not show a statistically significant difference in BP during the training session, our protocol may be an alternative to sedentary life and a determining factor where CVDs are concerned.

SUPPLEMENTARY MATERIALS

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